Antimicrobial therapy in newborns: from theory to practice

Currently, there are no uniform accurate statistical data on the development of neonatal sepsis. This critical condition is difficult to diagnose in the early stages due to the lack of reliable markers with high prognostic value, and the use of currently available sepsis markers with high specificity and/or sensitivity is limited to large tertiary level obstetric hospitals. In this regard, as part of the early diagnosis of neonatal sepsis, issues related to amultifactorial assessment of the risk of neonatal sepsis becoming relevant, on the basis of which indications for prescribing therapy for the prevention of this condition will be justified. The most common etiological cause of sepsis is numerous pathogens: bacteria, viruses and fungi. This again leaves difficulties in choosing the right therapeutic tactics, especially within the framework of antibiotic therapy, the protocols of which vary from hospital to hospital not only in our country, but throughout the world. Based on the practice of domestic and foreign colleagues, it is necessary to discuss protocols for the management of patients with such acomplex diagnosis as sepsis.