WTAP-mediated m <sup>6</sup> A modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1
TRIM22 silencing inhibited the progression of DN by interacting with OPA1 and inducing its ubiquitination. Furthermore, WTAP promoted m<sup>6</sup>A modification of TRIM22 via IGF2BP1.
Authors
- Xinyi Zhang (ORCID: https://orcid.org/0009-0003-7307-1256)
- Duanchun Zhang (ORCID: https://orcid.org/0009-0004-9103-4843)
- F J Zhou (ORCID: https://orcid.org/0009-0002-5443-4085)
- Zeng Zhang (ORCID: https://orcid.org/0009-0009-4654-9254)
- Siyu Xu
- Yanming He (ORCID: https://orcid.org/0000-0001-9985-0459)
- Min Lu (ORCID: https://orcid.org/0000-0002-2499-1449)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Suzhou Municipal Hospital (CN)
- Yueyang Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1080/13510002.2024.2404794
- Citations
- 13
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China