GDF15 antagonism limits severe heart failure and prevents cardiac cachexia
Our data suggest that cardiac stress mediates a GDF15-dependent pathway that drives weight loss and worsens cardiac function. Blockade of GDF15 could constitute a novel therapeutic option to limit cardiac cachexia and improve clinical outcomes in patients with severe systolic heart failure.
Authors
- Ali Al-Hadithi (ORCID: https://orcid.org/0000-0003-0417-9653)
- Shazia Absar
- Jane Goodall (ORCID: https://orcid.org/0000-0002-3761-161X)
- Stephen O’Rahilly (ORCID: https://orcid.org/0000-0003-2199-4449)
- Borja Ibáñez (ORCID: https://orcid.org/0000-0002-5036-254X)
- Minoru Takaoka (ORCID: https://orcid.org/0000-0002-8515-8282)
- J. Harrison (ORCID: https://orcid.org/0000-0003-2906-5097)
- Marcus Au (ORCID: https://orcid.org/0000-0003-2929-1019)
- Jasper Tromp (ORCID: https://orcid.org/0000-0001-6043-0713)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Xiaohui Zhao (ORCID: https://orcid.org/0000-0001-9922-2815)
- Eduardo Oliver (ORCID: https://orcid.org/0000-0001-9340-882X)
- Stefan John Marciniak (ORCID: https://orcid.org/0000-0001-8472-7183)
- Debra Rimmington (ORCID: https://orcid.org/0000-0002-3715-3970)
- Anthony P. Coll (ORCID: https://orcid.org/0000-0003-2594-7463)
- John A. Tadross (ORCID: https://orcid.org/0000-0002-8424-1252)
- Ziad Mallat (ORCID: https://orcid.org/0000-0003-0443-7878)
- Rocío Villena-Gutiérrez (ORCID: https://orcid.org/0000-0003-3849-4061)
Institutions
- University Medical Center Groningen (NL)
- Inserm (FR)
- National University of Singapore (SG)
- University of Groningen (NL)
- Université Paris Cité (FR)
- University of Cambridge (GB)
- Spanish National Centre for Cardiovascular Research (ES)
- Cambridge School (PT)
- Sorbonne Paris Cité (FR)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Bridge University (SS)
- East Midlands Academic Health Science Network (GB)
- Centro de Investigación Biomédica en Red (ES)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Paris Cardiovascular Research Center (FR)
- Centro de Investigaciones Biológicas Margarita Salas (ES)
- National University Health System (SG)
- Medical Research Council (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1093/cvr/cvae214
- Citations
- 30
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 14.10
Funders
- Medical Research Council