Crosslink reaction of α-/ω-substituted diacrylate polyethylene-glycol in Fmoc-FF hydrogel matrices

Peptides can form supramolecular gels, as N -9-fluorenylmethoxycarbonyl protected diphenylalanine (Fmoc-FF). [1] The Fmoc-FF hydrogel functional properties are modified incorporating additional entity.Multicomponent matrices of Fmoc-FF and diacrylate -/-substituted polyethylene glycol derivatives (PEGDAs) were formulated, by using two different PEGDA molecular weight (575 and 250 Da for PEGDA1 and PEGDA2, respectively) at different molar peptide/polymer ratio (1/1, 1/2, 1/5 ,1/10). [2] The acrylate moieties were cross-linked by UV irradiation at 365 nm, thus production no-covalent/covalent interpenetrated networks (IPNs).The properties of final materials (in terms of permeability, rheological response, and topography) were modulated by tuning the polymerization time. [3]