Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies
PYR is able to slightly decrease BP and HR in SHR rats but effectively increase BRS through vagal potentiation. The specific differences in protein expression profiles in rat myocardium induced by treatment with PYR and TRA reflect different mechanisms of action of these two agents at the molecular level.
Authors
- Jaroslav Hrdlička
- Almos Boroš
- Josef Zicha (ORCID: https://orcid.org/0000-0001-6051-6541)
- Jiřı́ Novotný (ORCID: https://orcid.org/0000-0002-6372-0131)
- Jan Neckář
- Michal Behuliak
- Zdeňka Drastichová (ORCID: https://orcid.org/0000-0003-3539-6634)
- Lucie Hejnová (ORCID: https://orcid.org/0000-0002-0629-8798)
Institutions
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fcvm.2024.1390547
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Grantová Agentura České Republiky