APP-CD74 axis mediates endothelial cell-macrophage communication to promote kidney injury and fibrosis
Our study unravels a compelling molecular mechanism, elucidating how endothelium-mediated regulation shapes macrophage function during renal repair. The identified APP-CD74 signaling axis emerges as a promising target for optimizing renal recovery post-injury and preventing the progression of chronic kidney disease.
Authors
- Yu-Xiong Wang (ORCID: https://orcid.org/0000-0003-1195-2739)
- Yunkuo Li (ORCID: https://orcid.org/0000-0002-1012-8265)
- Honglan Zhou
- Faping Li (ORCID: https://orcid.org/0000-0003-3016-5159)
- Yishu Wang
- Xin Gao
- Bin Liu
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fphar.2024.1437113
- Citations
- 18
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Natural Science Foundation of Jilin Province
- National Natural Science Foundation of China