Regulatory CD4+ T cells redirected against pathogenic CD8+ T cells protect NOD mice from development of autoimmune diabetes
Our results suggest a novel therapeutic strategy to protect NOD mice by targeting antigen-specific cytotoxic CD8<sup>+</sup> T cells, using redirected antigen-specific CD4<sup>+</sup> Treg cells, to suppress autoimmune diabetes. This may suggest an innovative therapy for protection of people at risk of development of type 1 diabetes.
Authors
- Hadas Weinstein-Marom (ORCID: https://orcid.org/0000-0002-2445-8222)
- Dimitri Kakabadse
- Joanne Davies (ORCID: https://orcid.org/0000-0002-3742-761X)
- F. Susan Wong (ORCID: https://orcid.org/0000-0002-2812-8845)
- Sigal Fishman (ORCID: https://orcid.org/0000-0002-4411-2501)
- Dawei Chen (ORCID: https://orcid.org/0000-0002-7486-1992)
- Wen Li (ORCID: https://orcid.org/0000-0002-8805-2934)
- Gideon Gross
Institutions
- Yale University (US)
- Migal - Galilee Technology Center (IL)
- Tel Hai Academic College (IL)
- Cardiff University (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1463971
- Citations
- 5
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- Juvenile Diabetes Research Foundation United States of America
- Diabetes UK
- BIRAX
- National Institutes of Health
- Medical Research Council