Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures
<i>Acod1</i> is robustly upregulated in the lungs following LPS exposure and encodes a key immunometabolic regulator. ACOD1 mediates the proinflammatory response to acute inhaled environmental LPS and organic dust exposure-induced lung inflammation.
Authors
- Tammy Kielian (ORCID: https://orcid.org/0000-0001-7624-670X)
- Vinai C. Thomas (ORCID: https://orcid.org/0000-0002-7886-0727)
- Todd A. Wyatt (ORCID: https://orcid.org/0000-0002-9273-6730)
- Jill A. Poole (ORCID: https://orcid.org/0000-0002-6236-2563)
- Peng Xiao (ORCID: https://orcid.org/0000-0001-5187-0119)
- Geoffrey M. Thiele (ORCID: https://orcid.org/0000-0001-5688-8596)
- Kristina L. Bailey (ORCID: https://orcid.org/0000-0003-2990-9042)
- Chittibabu Guda (ORCID: https://orcid.org/0000-0002-5393-9316)
- Aaron Schwab (ORCID: https://orcid.org/0000-0003-1142-7790)
- Dhananjay Shinde (ORCID: https://orcid.org/0000-0003-4682-0699)
- Oliver Schanze
- Amy Nelson
- Angela Gleason
Institutions
- Nebraska Medical Center (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1432334
- Citations
- 8
- Primary Topic
- Pediatric health and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.95
Funders
- University of Nebraska Medical Center
- National Institutes of Health
- Fred and Pamela Buffett Cancer Center
- National Cancer Institute
- National Institute of General Medical Sciences
- National Center for Research Resources