Genistein mitigates diet-induced obesity and metabolic dysfunctions in gonadectomized mice with some sex-differential effects
Genistein treatment mitigates DIO-related MASLD in both male and female gonadectomized mice. Regarding hepatic gene expression associated with MASLD and IR, the beneficial effect of genistein was significantly evident only in female mice. This study suggests a potential alternative application of genistein in individuals with obesity and sex hormone deprivation, yet pending clinical trials.
Authors
- Kasiphak Kaikaew (ORCID: https://orcid.org/0000-0002-1790-1839)
- Chuti Burana (ORCID: https://orcid.org/0000-0003-1053-1545)
- Pachara Varachotisate (ORCID: https://orcid.org/0000-0003-3791-4669)
- Duangporn Werawatganon (ORCID: https://orcid.org/0000-0001-8847-9690)
- Weerapat Kositanurit (ORCID: https://orcid.org/0000-0003-1294-7800)
- Jerasit Surintrspanont (ORCID: https://orcid.org/0000-0001-9755-0241)
- Narittee Sukswai (ORCID: https://orcid.org/0000-0001-8513-8153)
- Natakorn Siritaweechai (ORCID: https://orcid.org/0000-0003-3170-1523)
- Prasong Siriviriyakul (ORCID: https://orcid.org/0000-0003-3634-4158)
Institutions
- Thai Red Cross Society (TH)
- Chulalongkorn University (TH)
- King Chulalongkorn Memorial Hospital (TH)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fendo.2024.1392866
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Chulalongkorn University