Bushen Huoxue formula attenuates lipid accumulation evoking excessive autophagy in premature ovarian insufficiency rats and palmitic acid-challenged KGN cells by modulating lipid metabolism
These findings suggest that BHF alleviates the symptoms of POI by altering lipid metabolism and reducing lipid accumulation-induced ROS and autophagy, offering evidence for BHF's efficacy in treating POI clinically.
Authors
- Yahong Zhou (ORCID: https://orcid.org/0000-0002-2482-1976)
- Li Tian (ORCID: https://orcid.org/0000-0001-7359-7571)
- Peijuan Wang (ORCID: https://orcid.org/0000-0003-3648-1355)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-8402-9753)
- Xia Sun
- Beibei Zhou
- Yao Wei
- Xinlan Bian
- Rui Hao
- Beibie Jiao
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fphar.2024.1425844
- Citations
- 6
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.26
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province