LC-MS/MS-based metabolomics and proteomics reveal the intervention of Kangnian decoction on the postoperative intestinal adhesion of rats
This study proved that KN reduces intestinal mucosal injury, downregulates inflammatory factors, and alleviates intestinal adhesions, thus protecting the intestinal barrier function in PIA rats. The combination of proteomics and metabolomics provided a feasible approach for unraveling the therapeutic mechanism of KN decoction in PIAs.
Authors
- Liang Jin (ORCID: https://orcid.org/0000-0003-1695-3300)
- Long Chen (ORCID: https://orcid.org/0000-0001-5907-6374)
- Xinhua Liu (ORCID: https://orcid.org/0000-0002-9972-8215)
- Xiaotong Lu (ORCID: https://orcid.org/0000-0001-6926-9022)
- Lingyun Pan (ORCID: https://orcid.org/0000-0002-9979-5645)
- Jingwen Feng
- Xiaojing Qian
- Yuan Zhao
Institutions
- XinHua Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.3389/fphar.2024.1382760
- Citations
- 2
- Primary Topic
- Intestinal and Peritoneal Adhesions
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Science and Technology Commission of Shanghai Municipality