Oleuropein enhances proteasomal activity and reduces mutant huntingtin-induced cytotoxicity
We demonstrated that oleuropein enhances the degradation of mHtt by increasing proteasomal protease activities and alleviates mHtt-induced cytotoxicity. Hence, we propose that oleuropein and potentially other polyphenols hold promise as a candidate for alleviating Huntington's disease.
Authors
- Zih-Ting Huang
- Jie-Mao Chen
- Lu‐Shiun Her (ORCID: https://orcid.org/0000-0003-3665-6100)
- Zih-Ning Huang
- Sin-Yi Lee
Institutions
- National Cheng Kung University (TW)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-13
- DOI
- https://doi.org/10.3389/fphar.2024.1459909
- Citations
- 2
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- CHDI Foundation
- Cure Huntington's Disease Initiative
- Academia Sinica
- Jinan University
- National Cheng Kung University
- National Science and Technology Council