Investigating the Effect of Opium Addiction on Serum Glucose and Lipid Profiles in Diabetic Patients with Acute Coronary Syndromes

Background: Opium is one of the most commonly abused substances in Iran. Understanding the relationship between unhealthy drug use and clinical outcomes is essential due to its public health implications. Objectives: This study aimed to investigate the effect of opium addiction on serum glucose and lipid profiles in diabetic patients with acute coronary syndromes (ACS). Methods: In this cross-sectional study, 99 diabetic patients with ACS were examined. Demographic characteristics and laboratory parameters including hemoglobin A1c (HbA1c), fasting blood sugar (FBS), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG) were recorded. Patients were divided into two groups: Those who used opium and those who did not. All variables were compared between the two groups. Data analysis was performed using SPSS version 18. Results: The mean age of patients in the opium and non-opium groups was 47.4 ± 11.01 and 47.5 ± 11.12 years, respectively. There was no significant difference between the groups in terms of serum glucose levels (P > 0.05). Additionally, no significant difference was found in TG, total cholesterol, LDL, and HDL between patients who used opium and those who did not (P > 0.05). Conclusions: This study found that opium use did not have any positive or negative effect on serum glucose levels or lipid profiles in diabetic patients with ACS. Therefore, our results cannot be generalized with certainty.