In-utero transfer of decidualized endometrial stromal cells increases the frequency of regulatory T cells and normalizes the abortion rate in the CBA/J × DBA/2 abortion model
Our results showed that the deficiency of Tregs is not the primary driver of abortion in the CBA/J × DBA/2 model and provided evidence that impaired endometrial decidualization probably triggers endometrial immune dysfunction and abortion in this model.
Authors
- Haleh Edalatkhah
- Mohammad-Reza Shokri
- Bahman Zeynali (ORCID: https://orcid.org/0000-0002-5112-4287)
- Negar Vanaki
- Haleh Soltanghoraee (ORCID: https://orcid.org/0000-0003-4422-800X)
- Amir‐Hassan Zarnani (ORCID: https://orcid.org/0000-0003-4503-299X)
- Nasim Maslehat-Lay
- Ebrahim Mirzadegan (ORCID: https://orcid.org/0000-0003-3904-9242)
- Kayhan Zarnani
- Sedigheh Vafaei
- Mahmood Jeddi‐Tehrani (ORCID: https://orcid.org/0000-0002-8831-4711)
- Farnoosh Attari (ORCID: https://orcid.org/0000-0001-8964-2293)
- Kimia Zarnani
- Mohammad-Mehdi Naderi
- Ali Sarvari
Institutions
- University of Tehran (IR)
- Academic Center for Education, Culture and Research (IR)
- Moffitt Cancer Center (US)
- Biotechnology Research Center (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.3389/fimmu.2024.1440388
- Citations
- 4
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.96