Hesperetin Attenuates T-2 Toxin-Induced Chondrocyte Injury by Inhibiting the p38 MAPK Signaling Pathway
T-2 toxin activates the p38 MAPK signaling pathway, causing knee cartilage damage in rats. Treatment with hesperetin inhibits the p38/MEF2C signaling axis, regulates collagen II and MMP13 protein expression, and reduces cartilage injury significantly.
Authors
- Wenjing Yang (ORCID: https://orcid.org/0009-0008-8722-2269)
- Yi Ji (ORCID: https://orcid.org/0000-0002-9289-9660)
- Zhipeng Liu (ORCID: https://orcid.org/0000-0002-5458-9362)
- Dianjun Sun (ORCID: https://orcid.org/0000-0003-1701-4305)
- Chunqing Lu
- Zhe Jiao (ORCID: https://orcid.org/0000-0002-4600-8927)
- Hongna Sun (ORCID: https://orcid.org/0000-0003-4590-4532)
- Shaoxiao Qin
- Fang Chu
- Sheng Wang (ORCID: https://orcid.org/0009-0008-6659-2367)
- Hao Yu (ORCID: https://orcid.org/0009-0008-6002-6276)
Institutions
- Harbin Medical University (CN)
- Chinese Center For Disease Control and Prevention (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-09-14
- DOI
- https://doi.org/10.3390/nu16183107
- Citations
- 5
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.24