Oxandrolone use causes dyslipidemia in resistance-training practitioners
Objective: This study investigated blood and salivary parameters in male resistance-training practitioners (RTP) using oxandrolone (OG) and compared with references values and control group (CG), in triplicate. Methods: Blood, saliva, and urine were collected from 22 individuals (OG, n = 11 / CG, n = 11) and analyzed: before oxandrolone (OX) consumption (T1), at cessation of OX use (T2), and three months after cessation of OX use (T3). Complete blood count, lipid profile, metabolites, and enzymes were analyzed from blood samples. Salivary flow, pH, triglycerides, urea, aspartate animotransferase, alanine aminotransferase, phosphorus, and calcium were analyzed from saliva. Urinalysis was used for toxicological screening. Results: A reduced hdl cholesterol level was observed in the og group (24 mg/dL) compared with the reference value (>40 mg/dL) at T2. HDL levels return to normal after cessation AT T3 (49 mg/dL, >40 mg/dL). A higher triglyceride level (177 mg/dL) was verified in OG group compared with the reference value (<175 mg/dL) at T3. Conclusions: The results of this study suggest that oxandrolone use is associated with changes in lipid profiles, including lower HDL levels and higher triglyceride levels, which are characteristic of dyslipidemia. however, while these findings indicate an association, they do not establish definitive causality. further research, including well-controlled longitudinal studies, is needed to confirm the causal relationship between oxandrolone use and dyslipidemia.
Authors
- Edvaldo Antônio Ribeiro Rosa (ORCID: https://orcid.org/0000-0001-6087-4365)
- Leonardo Cesar Santos de Barros (ORCID: https://orcid.org/0000-0003-4493-4561)
- Julia Souto de Jesus (ORCID: https://orcid.org/0000-0002-5217-338X)
- João Armando Brancher (ORCID: https://orcid.org/0000-0002-8914-702X)
- Everdan Carneiro (ORCID: https://orcid.org/0000-0002-7883-5396)
- Aline Cristina Batista Rodrigues Johann (ORCID: https://orcid.org/0000-0002-1678-9363)
- Ericson Pereira (ORCID: https://orcid.org/0000-0002-1449-9004)
- Eduardo Mendonça Scheeren (ORCID: https://orcid.org/0000-0003-3014-856X)
- Tiago Bittencourt de Oliveira (ORCID: https://orcid.org/0000-0003-4598-0922)
- Fernanda Tiboni (ORCID: https://orcid.org/0000-0002-2511-8019)
- Sérgio Aparecido Ignácio (ORCID: https://orcid.org/0000-0002-8242-3781)
- Marlene Barros (ORCID: https://orcid.org/0000-0003-0631-4062)
- Flávia Auler (ORCID: https://orcid.org/0000-0002-2319-9089)
- Renata Iani Werneck (ORCID: https://orcid.org/0000-0003-1134-5357)
- Pamela Rafaela Martins (ORCID: https://orcid.org/0000-0001-7217-9888)
- Thiago Beltrami Dias Batista (ORCID: https://orcid.org/0000-0003-1224-0637)
- Letícia Birk (ORCID: https://orcid.org/0000-0002-9229-5840)
- Dênis de Lima Greboggy (ORCID: https://orcid.org/0000-0003-3114-7358)
- Milena Fernandes dos Santos (ORCID: https://orcid.org/0000-0001-9403-0582)
- Yesudian Yamada da Gama (ORCID: https://orcid.org/0000-0003-0748-2519)
- Maria Heloisa Madruga Chaves (ORCID: https://orcid.org/0000-0003-2696-9824)
- Sarah Carobini Werner de Souza Eller (ORCID: https://orcid.org/0000-0003-2200-6959)
- Salma Ali El Chab Parolin (ORCID: https://orcid.org/0000-0002-4811-9727)
- Mariana Hornung Marins (ORCID: https://orcid.org/0009-0008-7877-4360)
Institutions
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- Universidade Católica Portuguesa (PT)
Publication Details
- Journal
- Research Society and Development
- Published
- 2024-09-21
- DOI
- https://doi.org/10.33448/rsd-v13i9.46803
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00