Use of Oral Gentamicin in Children with Primary Immunodeficiency and Recurrent Campylobacter coli Bacteremia: A Case Report

Immunosuppressed patients are more at risk of suffering bacteremias due to atypical microorganisms such as Campylobacter coli, which can colonize their intestinal mucosa due to the absence of IgA, the main immunoglobulin of the mucosa and which is not provided with intravenous or subcutaneous immunoglobulin treatment. We have recently had a case of a 5-year-old girl with autosomal recessive agammaglobulinemia with recurrent Campylobacter coli bacteremia and positive stool cultures for the same microorganism. She was treated with intravenous antibiotherapy and given the recurrence of bacteremia, oral gentamicin was associated with this treatment to try to achieve intestinal eradication of the germ. Oral gentamicin was well tolerated, gave no side effects, and managed to eradicate the microorganism 6 months after the end of treatment. We want to reflect the scarce literature on the use of oral gentamicin, the dose and duration of treatment, and the good evolution of our patient with the regimen used.