Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization
Our findings demonstrated oroxylin A suppressed psoriasiform skin inflammation in mouse models by blocking the PKCζ-p62 interaction, subsequently inhibiting the activation of NF-κB p65 phosphorylation in macrophages.
Authors
- Leyi Chen (ORCID: https://orcid.org/0000-0002-7090-3788)
- Yujiao Xu
- You Zhong
- Xiangzheng Li
- Lei Qiang (ORCID: https://orcid.org/0000-0002-7164-3164)
- Yunyao Liu
- Yuan He (ORCID: https://orcid.org/0000-0002-1712-0776)
- Xu Chen (ORCID: https://orcid.org/0000-0003-4303-8116)
- Yuxiang Ma (ORCID: https://orcid.org/0000-0003-1173-8441)
- He Huang (ORCID: https://orcid.org/0000-0002-4682-8335)
- Litong Gong
Institutions
- China Pharmaceutical University (CN)
- Guilin Medical University (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Taiwan Semiconductor Manufacturing Company (China) (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1111/bph.17349
- Citations
- 11
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 2.65
Funders
- National Natural Science Foundation of China
- China Pharmaceutical University
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Chinese Academy of Medical Sciences
- Peking Union Medical College
- Guilin Medical University