Tumor-Associated Neutrophils Are a Negative Prognostic Factor in Early Luminal Breast Cancers Lacking Immunosuppressive Macrophage Recruitment
CD66b+ neutrophils were a negative prognostic factor in early-stage luminal breast cancer in single-marker analysis. Combined analysis with TAMs could be necessary to correctly evaluate their prognostic impact in future studies. TAN recruitment might act as a compensatory mechanism of immunoevasion and disease progression in tumors that are unable to sufficiently attract and polarize TAMs.
Authors
- Carolin C. Hack (ORCID: https://orcid.org/0000-0002-2426-7020)
- Marie-Charlotte Rosahl
- Maike Büttner‐Herold (ORCID: https://orcid.org/0000-0002-9974-6683)
- Rainer Fietkau (ORCID: https://orcid.org/0000-0001-8295-7145)
- Oliver Josef Ott (ORCID: https://orcid.org/0000-0001-5806-6158)
- Sören Schnellhardt (ORCID: https://orcid.org/0000-0003-0418-4401)
- Arndt Hartmann (ORCID: https://orcid.org/0000-0002-4860-4626)
- Markus Hecht (ORCID: https://orcid.org/0000-0003-2082-216X)
- Ramona Erber (ORCID: https://orcid.org/0000-0003-0315-1229)
- Luitpold Valentin Distel (ORCID: https://orcid.org/0000-0002-8040-3226)
- Vratislav Strnad
- Eva Schmidt
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Comprehensive Cancer Center Erlangen (DE)
- Saarland University (DE)
Publication Details
- Journal
- Cancers
- Published
- 2024-09-15
- DOI
- https://doi.org/10.3390/cancers16183160
- Citations
- 10
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.40