Design and synthesis of novel metallophthalocyanines via two step reactions as potential antimicrobial agents starting with new synthesized phthalonitrile derivatives: Complexation, Extraction and antimicrobial studies

New phthalonitrile derivatives 1-4 were considered as the key intermediates for the synthesis of new phthalocyanines. Their capacity to bind various transition metal and heavy metal cations was studied in methanol. The absorbance and conductivity were measured using UV spectrophotometry. Spectral and elemental investigations revealed the structures of the newly synthesized phthalocyanines. The complexes formed were analyzed, and their stability constants were determined through digital data processing. The ability of water to extract these compounds in dichloromethane was also examined. It was discovered that compound 1 had a lower affinity for metal picrates compared to compound 2-4, especially Fe(III). The stoichiometry of the complex was confirmed by conducting conductivity studies. The antimicrobial properties of the novel compounds were investigated, and it has been established that have compounds 9, 12 and 13 potent inhibitory activities against both Gram-positive and Gram negative bacteria and fungi.