Slow negative potentials in the pre-stimulus period in norm and patients with the first episode of schizophrenia

Behavioral data (correct response latency and errors number increase) indicate a significant decrease in the task performance efficiency in patients with the first episode of schizophrenia, compared to the norm. At the same time the SNP 1, 2, 3 amplitudes were found to enhance in the patients group, compared to the norm, which may reflect a compensatory activation of predictive attention and inhibition cortical networks for increase the response efficiency. Intergroup differences in the topography of the SNP1 and SNP2 peaks amplitude suggest “disorganization” of the left hemisphere cognitive control cortical networks at the early stage of schizophrenia. It is assumed that the SNP 1, 2, 3 components can be considered as potentially significant clinically markers of cognitive control disorders in schizophrenia.