P050 Purine metabolites in preeclampsia and cerebral ischemia

<h3></h3> <b>Please confirm that an ethics committee approval has been applied for or granted</b>: Not relevant (see information at the bottom of this page) <h3>Background and Aims</h3> It has been established that hypoxanthine, xanthine and uric acid are present in the brain, their content changes after ischemia, uric acid is the end product of purine degradation in the brain, xanthine oxidase is also present in the brain, catalyzes the oxidation of hypoxanthine to xanthine, and then to uric acid, and can be a source of free radicals. The results of many years of studies of the effects of parenteral use of uric acid in acute ischemic stroke have been published; it has been established that its parenteral administration in patients with cerebral stroke can reduce secondary reperfusion damage to ischemic tissue, and improve the neurological outcome. <h3>Methods</h3> The study involved 33 women with preeclampsia and 350 women in acute period of cerebral stroke, inwhich, in addition to conventional laboratory parameters were determined in blood and cerebrospinalfluid - guanine, hypoxanthine, adenine, xanthine and uric acid by direct spectrophotometry. <h3>Results</h3> It was established that between preeclampsia and cerebral stroke there are clinical andpathobiochemical parallels, including according to the characteristics of purine metabolism.Hyperuricemia the most famous and at the same time the most pronounced adverse metabolic factor(marker or predictor) for preeclampsia, and for cerebral stroke. High value level of oxypurines(hypoxanthine, xanthine and uric acid) in the cerebrospinal fluid is good sign for a stroke, and low valuelevel of oxypurines is good sign for preeclampsia. <h3>Conclusions</h3> Cerebrospinal liquor can be seen not only medium of administration of drugs for spinal anesthesia, butalso and a source of valuable diagnostic (and predictive) information