Heat transfer simulation of optogenetics-LED based on microchannel heat dissipation

Optogenetics technology has greatly promoted the development of neuroscience. Flexible gene manipulation tools and sensitive light activation methods have provided convenience for neural function research. However, the thermal effect generated in the process of light stimulation affects the activation of neurons by optogenetic technology, which makes the results of light-activated light-sensitive proteins to generate neural currents inaccurate. Here, we established an in vivo activation model of LED-based optogenetic technology through simulation and analyzed the thermal effect produced by it. We propose to use microchannels to dissipate heat from implanted devices, reducing the thermal effect of light stimulation for neural activation. Through simulation, we propose the use of the vortex-like and cobweb-like microchannels for heat dissipation, which can control the temperature rise within 0.28K and 0.31K, respectively.