Efficacy and mechanism of action of ginsenoside Rg3 on radiation proctitis in rats
Thus, GRg3 may reduce the inflammatory response by blocking the NF-κB signaling pathway and improving the balance of inflammation-related factors. GRg3 may also inhibit intestinal cell apoptosis by suppressing the TNF-α/caspase-8 signaling cascade, thereby reducing radiological rectal injury. Our results verify that GRg3 is a promising therapeutic agent for RP treatment and shed light on its mechanism.
Authors
- Xiaoyu Duan
- Tingting Hu (ORCID: https://orcid.org/0000-0002-7304-9433)
- Lili Lin (ORCID: https://orcid.org/0000-0001-8723-6793)
- Hongyi Cai (ORCID: https://orcid.org/0000-0002-8021-8493)
- Jiuju Dai
- Xuxia Li (ORCID: https://orcid.org/0009-0001-8693-7739)
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/iid3.70015
- Citations
- 3
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 1.21