Associations between single nucleotide polymorphisms of cytokines and hepatitis B virus‐related liver cirrhosis: A case‐control study
Polymorphisms rs1800896 and rs2227306 are potentially associated with the risk of cirrhosis. For the first time, the study highlights that the rs2055979 AA/AC and rs1799964 CC/CT polymorphism interact with gender and its potential reversal of cirrhosis risk in males. Furthermore, rs1800896 AA showed a synergistic effect with rs1799964 TT and rs1799724 CT/TT to prevent the progression of HBV infection to cirrhosis.
Authors
- Xiaojie Yuan (ORCID: https://orcid.org/0000-0003-2690-422X)
- Chunhui Liang
- Weikang Wu
- Wenling Jia
- Haowei Zhou (ORCID: https://orcid.org/0000-0002-0638-1487)
- Yancheng Ye (ORCID: https://orcid.org/0000-0001-6094-4271)
- Haitao Tang (ORCID: https://orcid.org/0009-0001-4455-1918)
- Zhongjun Shao (ORCID: https://orcid.org/0000-0002-3236-3629)
- Wen‐Hua Zhang (ORCID: https://orcid.org/0000-0001-9047-8881)
- Fengmei Wang (ORCID: https://orcid.org/0000-0002-9438-9859)
- Yijun Li (ORCID: https://orcid.org/0000-0002-1699-1510)
Institutions
- Air Force Medical University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/iid3.70017
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shaanxi Province