Diabetes-Related Changes in Carotid Wall Properties: Role of Triglycerides

<b>Background/Objectives:</b> This study compares the power of the radiofrequency (RF) signal reflected from the media layer (media power) of the common carotid artery (CCA) and the CCA stiffness between individuals with and without type 2 diabetes mellitus (T2DM). It also evaluates the associations of CCA media power with plasma glucose and lipid levels, as well as carotid stiffness. <b>Methods:</b> A total of 540 individuals, 115 with and 425 without T2DM (273 males, mean age = 64 ± 8 years) were studied using RF-based tracking of the right CCA. The following parameters were measured: CCA media thickness, luminal diameter, wall tensile stress (WTS), local pulse wave velocity (PWV), and media power. <b>Results:</b> Compared to the non-diabetic individuals, the T2DM patients had significantly higher CCA media thickness (652 ± 122 vs. 721 ± 138 microns, <i>p</i> < 0.005), luminal diameter (6.12 ± 0.78 vs. 6.86 ± 0.96 mm, <i>p</i> < 0.0005), media power (36.1 ± 4.8 vs. 39.3 ± 4.6, <i>p</i> < 0.0001), and PWV (7.65 ± 1.32 vs. 8.40 ± 1.89 m/s; <i>p</i> < 0.01), but comparable WTS (32.7 ± 10.4 vs. 33.1 ± 10.7 kPa; <i>p</i> = 0.25). In the entire population, CCA media power was independently associated with male sex, pulse pressure, current smoking, and T2DM; when T2DM was not included in the model, triglycerides emerged as an independent determinant of media power. The CCA PWV was independently associated with age, pulse pressure, media power, and T2DM. <b>Conclusions:</b> Our findings suggest the presence of structural changes in the arterial media of T2DM patients, leading to carotid stiffening and remodeling, aiming to preserve WTS. T2DM-related changes in arterial wall composition may be driven by high plasma triglyceride levels, which have previously been associated with both arterial stiffening and the incidence of CV events.