Mechanisms of GTN-induced migraine: Role of NOS isoforms, sGC and peroxynitrite in a migraine relevant mouse model
Migraine-relevant hypersensitivity induced by GTN is mediated by a possible feed-forward phenomenon of NO driven mainly by iNOS but with contributions from other isoforms. The involvement of peroxynitrite adds to the notion that oxidative stress reactions are also involved.
Authors
- Song Guo (ORCID: https://orcid.org/0000-0003-1168-165X)
- David M. Kristensen (ORCID: https://orcid.org/0000-0003-0657-1632)
- Karina Obelitz‐Ryom (ORCID: https://orcid.org/0000-0002-2771-4842)
- Charlotte Ernstsen (ORCID: https://orcid.org/0000-0003-0455-1902)
- Sarah Louise Christensen (ORCID: https://orcid.org/0000-0002-7985-4783)
- Jes Olesen
Institutions
- Roskilde University (DK)
- University of Copenhagen (DK)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Inserm (FR)
- École des Hautes Études en Santé Publique (FR)
- Glostrup Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Institut de Recherche en Santé, Environnement et Travail (FR)
Publication Details
- Journal
- Cephalalgia
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1177/03331024241277542
- Citations
- 3
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Novo Nordisk
- Copenhagen Graduate School for Nanoscience and Nanotechnology
- Torben og Alice Frimodts Fond
- Faculty of Health and Medical Sciences, University of Western Australia
- Novo Nordisk Fonden
- Candys Foundation
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet