<i>Mycobacterium abscessus</i> strain variability in preclinical drug development: does it really matter?
Time- and concentration-dependent drug activity against the ATCC 19977 strain seems indicative for in vitro drug behaviour against M. abscessus complex clinical isolates. Including one clinical smooth morphotype isolate alongside ATCC 19977 seems appropriate for reliable interpretation of this particular in vitro drug activity assay as part of the M. abscessus preclinical drug development pipeline.
Authors
- Jurriaan E.M. de Steenwinkel (ORCID: https://orcid.org/0000-0001-8437-1025)
- Nicole C. Ammerman (ORCID: https://orcid.org/0000-0001-9359-9144)
- Hannelore I. Bax (ORCID: https://orcid.org/0000-0003-0076-5479)
- Saskia E Mudde (ORCID: https://orcid.org/0000-0002-9910-156X)
- Henriëtte M Meliefste
Institutions
- Erasmus MC (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1093/jac/dkae336
- Citations
- 4
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.55