[NRF2 mediated redox stress in arsenic induced human keratinocytes malignant transformation].
In the early stage(1st, 7th and 14th passages) of NaAsO_2 treated HaCaT cells, oxidative stress occurred with continuous high NRF2 expression. Later(21st, 28th and 35th passages), NRF2 induced reductive stress, leading to malignant transformation.
Authors
- Qianlei Yang
- Huiting Chen (ORCID: https://orcid.org/0000-0002-0281-4142)
- Yan An (ORCID: https://orcid.org/0000-0003-2838-8169)
- Guangze Yao
- Ting Zhang (ORCID: https://orcid.org/0000-0001-5676-4825)
Institutions
- Soochow University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-09-01
- DOI
- https://doi.org/10.19813/j.cnki.weishengyanjiu.2024.05.012
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article