IDENTIFICATION OF COMMON DIFFERENTIALLY EXPRESSED GENES (DEGS) AND HUB GENES IN NEURODEGENERATIVE DISEASES: A COMPARATIVE STUDY OF ALZHEIMER'S AND PARKINSON'S USING EXTENSIVE DATA MINING

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative disorders, sharing overlapping pathophysiological mechanisms. This study aims to identify common differentially expressed genes (DEGs) and hub genes between AD and PD using publicly available datasets from the Gene Expression Omnibus (GEO). We utilized datasets GSE5281 for AD and GSE49036 for PD to conduct a comparative analysis. After normalization and differential expression analysis, common DEGs were identified, followed by protein-protein interaction (PPI) network construction using the STRING database. Hub genes were extracted through Cytoscape's cytoHubba plugin based on centrality measures. The results highlight shared molecular pathways and key hub genes, including MAPT, SNCA, APP, and KLHL2, which may serve as potential therapeutic targets for both diseases. These findings contribute to a better understanding of the common molecular landscape in neurodegenerative diseases and open avenues for novel treatment strategies.