Kidney diseases in adolescents classified according to nomenclature for kidney function and disease (KDIGO 2019): a cross-sectional study of the regional register 2013-2022 years

Aim. To determine the structure of kidney diseases in 17-year-old adolescents before their transition to the adult healthcare system using the 2019 KDIGO. Methods. This single-center, cross-sectional descriptive study analysed a 10-year regional register of 893 adolescents hospitalized in the V.P. Sitnikova nephrology department at Voronezh Regional Children’s Clinical Hospital between 2013 and 2022. Kidney functions assessed using the CKiDbed (2009) and CKDEPI (2009) equations. Statistical significance was defined as a p <0.05. Results. Over 70% of all hospitalizations were related attributed renal tubulo-interstitial diseases (N10- N16), congenital malformations of the urinary system (Q60-Q64), and glomerular diseases (N00-N08). The distribution of kidney conditions included CKD (36.6%), AKD without AKI (14.9%), AKD combined with CKD (8.5%), AKI (0.4%), AKI combined with CKD (1.3%), and no kidney disease. CKD was more prevalent in males (69.5%, vs 45.3% in females, p <0.001), while AKD was more common in females (38.0% vs 15.1% in males). GFR calculation discrepancies between CKiDbed and CKD-EPI equations led to changes in GFR categories and CKD/AKD stages 55.8% of adolescents, with the largest median discrepancy in males (37 ml/min/1.73 m2). Conclusions. the study classified kidney diseases in 17-year-old, revealing gender differences and highlighting the impact of varying GFR calculation methods of disease staging. The findings emphasized the need for consistent GFR assessment approaches across pediatric and young adult healthcare.