Cytotoxic Lesions of the Corpus Callosum (CLOCCs) Related to Hypoglycemia: Clinical Insights and Pathogenesis

We describe the case of an 88-year-old man with cytotoxic lesions of the corpus callosum (CLOCCs) related to hypoglycemia. The patient developed a disturbance of consciousness following excessive alcohol consumption and anorexia. In the emergency room, his blood sugar level was 9 mg/dL, and he was immediately treated with a rapid infusion of glucose. Brain magnetic resonance imaging (MRI) revealed hyperintensity in the corpus callosum and bilateral deep white matter on diffusion-weighted imaging, along with decreased apparent diffusion coefficient values. The following day, these findings were attenuated, and he was diagnosed with CLOCCs. In this report, we discuss clinical insights and the possible pathogenesis of the development of CLOCCs due to hypoglycemia, considering the previous literature.