The challenged urine bicarbonate excretion test in cystic fibrosis: A comprehensive analysis of urine acid/base parameters
Following acute NaHCO<sub>3</sub>-loading, increased base excretion is mirrored by decreased acid excretion. Urine HCO<sub>3</sub> <sup>-</sup> excretion sufficiently represents the additional urine acid/base parameters as test result. The observed changes in acid excretion support CFTR modulator-induced increase of CFTR-dependent type B intercalated cell HCO<sub>3</sub> <sup>-</sup> secretion and the use of the challenged urine HCO<sub>3</sub> <sup>-</sup> test as a possible CFTR-biomarker.
Authors
- Søren Jensen‐Fangel
- Majbritt Jeppesen
- Mads Vaarby Sørensen (ORCID: https://orcid.org/0000-0001-6398-1035)
- Jens Leipziger (ORCID: https://orcid.org/0000-0002-6719-7034)
- Amalie Quist Rousing (ORCID: https://orcid.org/0009-0005-8762-4733)
- Peder Berg (ORCID: https://orcid.org/0000-0002-5216-2891)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1111/apha.14233
- Citations
- 4
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Innovationsfonden