A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations
Our findings highlight that an increase in the EC volume is the key mechanism driving the initial stages of AV shunt formation, leading to asymmetric capillary diameters. Based on our results, we propose a coherent and unifying timeline leading to the fast conversion of a capillary vessel into an AV shunt. Our data advocate for further investigation into the mechanisms regulating EC volume in health and disease as a way to identify therapeutic approaches to prevent and revert AVMs.
Authors
- Miguel O. Bernabéu (ORCID: https://orcid.org/0000-0002-6456-3756)
- Cláudio A. Franco (ORCID: https://orcid.org/0000-0002-2861-3883)
- Tiago Costa (ORCID: https://orcid.org/0000-0002-3666-7531)
- Lenka Henao Misikova (ORCID: https://orcid.org/0000-0002-0992-9946)
- Daniela Ramalho (ORCID: https://orcid.org/0000-0002-0904-2106)
- Nadine V. Conchinha (ORCID: https://orcid.org/0000-0002-4241-0396)
- Romain Enjalbert (ORCID: https://orcid.org/0000-0001-9685-5764)
- Andreia Pena (ORCID: https://orcid.org/0000-0003-1668-0891)
- Ana M. Figueiredo (ORCID: https://orcid.org/0000-0003-3499-9871)
- Marie Ouarné (ORCID: https://orcid.org/0000-0003-4724-4363)
- S. Paul Oh
- Yulia Carvalho (ORCID: https://orcid.org/0000-0003-3733-1690)
- Marta Pimentel Saraiva
Institutions
- Barrow Neurological Institute (US)
- University of Lisbon (PT)
- Universidade Católica Portuguesa (PT)
- University of Edinburgh (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1093/cvr/cvae160
- Citations
- 2
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- “la Caixa” Foundation
- European Commission
- Fondation Leducq
- European Research Council