A ROS‐Responsive Lipid Nanoparticles Release Multifunctional Hydrogel Based on Microenvironment Regulation Promotes Infected Diabetic Wound Healing
The continuous imbalance of the diabetic wound microenvironment is an important cause of chronic nonhealing, which manifests as a vicious cycle between excessive accumulation of reactive oxygen species (ROS) and abnormal healing. Regulating the microenvironment by suppressing wound inflammation, oxidative stress, and bacterial infection is a key challenge in treating diabetic wounds. In this study, ROS-responsive hydrogels are developed composed of silk fibroin methacrylated (SFMA), modified collagen type III (rCol<sub>3</sub>MA), and lipid nanoparticles (LNPs). The newly designed hydrogel system demonstrated stable physicochemical properties and excellent biocompatibility. Moreover, the release of antimicrobial peptide (AMP) and puerarin (PUE) demonstrated remarkable efficacy in eradicating bacteria, regulating inflammatory responses, and modulating vascular functions. This multifunctional hydrogel is a simple and efficient approach for the treatment of chronic diabetic infected wounds and holds tremendous potential for future clinical applications.
Authors
- Bing Tang (ORCID: https://orcid.org/0000-0001-5859-8250)
- Shanqiang Qu (ORCID: https://orcid.org/0000-0002-2709-0101)
- Dongming Lv (ORCID: https://orcid.org/0000-0001-9642-0410)
- Yongfei Chen
- Yanchao Rong (ORCID: https://orcid.org/0000-0001-9125-189X)
- Jiayuan Zhu (ORCID: https://orcid.org/0000-0003-1501-6999)
- Honglin Wu (ORCID: https://orcid.org/0000-0002-1175-5201)
- Xiaohui Li (ORCID: https://orcid.org/0000-0001-9653-9227)
- Zhiyong Wang (ORCID: https://orcid.org/0000-0001-9265-3719)
- Xiaoling Cao
- Shuting Li (ORCID: https://orcid.org/0000-0002-7670-689X)
- Zhicheng Hu (ORCID: https://orcid.org/0000-0002-0026-0676)
- Hao Yang (ORCID: https://orcid.org/0000-0002-5388-5039)
- Hailin Xu (ORCID: https://orcid.org/0000-0002-6448-7343)
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1002/advs.202403219
- Citations
- 63
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 15.74
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province