Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart
Together, we present ZEB2 as a central regulator of contractility and Ca2+-handling components in the mammalian heart. Further mechanistic understanding of the role of ZEB2 in regulating Ca2+ homeostasis in cardiomyocytes is an essential step towards the development of improved therapies for HF.
Authors
- Mariska van Geldorp
- Willem B. van Ham (ORCID: https://orcid.org/0000-0002-6621-148X)
- Lieneke Kooijman
- Monika M Gladka (ORCID: https://orcid.org/0000-0002-4094-4335)
- Anne E. de Leeuw (ORCID: https://orcid.org/0000-0001-8511-1794)
- Rocco Caliandro (ORCID: https://orcid.org/0000-0002-0368-4925)
- Toon A.B. van Veen (ORCID: https://orcid.org/0000-0002-4775-5924)
- Arwa Kohela (ORCID: https://orcid.org/0000-0002-4054-9407)
- Daniëlle Versteeg
- Eva van Rooij
- Bas Molenaar
- Jody J. Haigh (ORCID: https://orcid.org/0000-0002-7319-8922)
Institutions
- Royal Netherlands Academy of Arts and Sciences (NL)
- University Medical Center Utrecht (NL)
- Amsterdam University Medical Centers (NL)
- University of Manitoba (CA)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1093/cvr/cvae163
- Citations
- 7
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Fondation Leducq
- Hartstichting
- H2020 European Research Council