Microvascular effects of a mixed meal tolerance test: a model validation study
SDFM, PLM and LSCI LTH endpoints displayed high intra-subject variability and did not detect consistent effects of MMTT. LSCI PORH endpoints displayed the lowest intra-subject variability of all assessed endpoints and were affected by the MMTT on Day 1, but not on Day 84. Further standardization of methods or more robust challenges to affect vascular endpoints may be needed.
Authors
- Ines Warnke (ORCID: https://orcid.org/0000-0001-7739-8115)
- Marieke L. de Kam (ORCID: https://orcid.org/0000-0002-6351-0847)
- Femke P. M. Hoevenaars (ORCID: https://orcid.org/0000-0002-1207-925X)
- Matthijs Moerland (ORCID: https://orcid.org/0000-0002-8064-8426)
- Pim Gal (ORCID: https://orcid.org/0000-0001-7622-9029)
- Sebastiaan J. W. van Kraaij (ORCID: https://orcid.org/0000-0002-2465-1831)
- Boukje C. Eveleens Maarse (ORCID: https://orcid.org/0000-0003-1763-3122)
Institutions
- Netherlands Organisation for Applied Scientific Research (NL)
- Leiden University Medical Center (NL)
- Centre for Human Drug Research (NL)
Publication Details
- Journal
- Clinical Physiology and Functional Imaging
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1111/cpf.12904
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek