DNA Methylation Age Mediates Effect of Metabolic Profile on Cardiovascular and General Aging
These findings suggest that epigenomic mechanisms may play a role in the associations between circulating metabolites and the aging process. Different mechanisms underlie the first and second generations of DNA methylation age in cardiovascular and general aging.
Authors
- Iain Turnbull (ORCID: https://orcid.org/0000-0002-9913-1961)
- Qilian Jiang
- Chuanming Ni
- Xianping Wu (ORCID: https://orcid.org/0000-0002-9806-5309)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4399-2532)
- Xiaohuan Wang (ORCID: https://orcid.org/0000-0001-9034-1957)
- Daniel Avery (ORCID: https://orcid.org/0000-0002-9823-9575)
- Paul Sherliker (ORCID: https://orcid.org/0009-0003-9559-6029)
- Ningyu Chen (ORCID: https://orcid.org/0000-0001-6359-1176)
- Yajing Zang
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Yuelong Huang (ORCID: https://orcid.org/0009-0005-8372-2352)
- Jiaqiu Liu
- Andri Iona (ORCID: https://orcid.org/0000-0001-8042-9672)
- Jianrong Jin
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Can Hou (ORCID: https://orcid.org/0000-0002-6903-6007)
- Sajjad Rafiq (ORCID: https://orcid.org/0000-0003-4873-4540)
- Jinyan Chen (ORCID: https://orcid.org/0000-0003-4103-7056)
- Zengchang Pang (ORCID: https://orcid.org/0000-0003-4746-0074)
- LV Jun (ORCID: https://orcid.org/0000-0002-0801-5915)
- Yunlong Tan (ORCID: https://orcid.org/0000-0002-3522-3912)
- Jenny Wang (ORCID: https://orcid.org/0000-0002-1325-7943)
- Om Kurmi (ORCID: https://orcid.org/0000-0002-9518-4716)
- Xue W. Mei (ORCID: https://orcid.org/0000-0002-6279-4884)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Enke Mao
- Dan Schmidt (ORCID: https://orcid.org/0000-0003-0704-8165)
- Pan He (ORCID: https://orcid.org/0000-0002-6699-4082)
- Huaiyi Mu
- Ming Wu (ORCID: https://orcid.org/0000-0002-9542-6332)
- Liang Chang (ORCID: https://orcid.org/0000-0001-9552-519X)
- Xiaoyan Zheng (ORCID: https://orcid.org/0000-0002-2997-9756)
- Rajani Sohoni
- Xukui Zhang
- Richard Peto (ORCID: https://orcid.org/0000-0001-8219-5339)
- Robert Clarke (ORCID: https://orcid.org/0000-0002-9802-8241)
- Ying Huang (ORCID: https://orcid.org/0000-0002-7559-7070)
- Hairong Guan
- Meiling Dou
- Yan Lü (ORCID: https://orcid.org/0000-0002-2868-2352)
- Jiahui Si (ORCID: https://orcid.org/0000-0003-0827-4973)
- Liming Liang (ORCID: https://orcid.org/0000-0001-8261-3174)
- Ruying Hu (ORCID: https://orcid.org/0000-0002-5917-3454)
- Yu Min (ORCID: https://orcid.org/0000-0002-1266-3325)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-1105-9417)
- Xianzhi Li (ORCID: https://orcid.org/0000-0002-3653-4448)
- Jiyuan Yin
- Qiannan Lv
- Shanqing Wang (ORCID: https://orcid.org/0009-0004-5850-1470)
- Michael V. Holmes (ORCID: https://orcid.org/0000-0001-6617-0879)
- Christiana Kartsonaki (ORCID: https://orcid.org/0000-0002-3981-3418)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Yulian Gao
- Yan Fu (ORCID: https://orcid.org/0000-0001-8876-992X)
- Jayakrishnan Radhakrishnan (ORCID: https://orcid.org/0000-0002-6885-2010)
- Robin G. Walters (ORCID: https://orcid.org/0000-0002-9179-0321)
- Derrick Bennett (ORCID: https://orcid.org/0000-0002-9170-8447)
- Mingqiang Li (ORCID: https://orcid.org/0000-0002-5178-4138)
- Ruth Boxall (ORCID: https://orcid.org/0000-0003-0356-3549)
- Hu Chen (ORCID: https://orcid.org/0000-0002-5645-9449)
- Aiyu Tang
- Naying Chen
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Rene Kerosi
- Qunhua Nie
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Kaixue Xie
- Yuanjie Pang (ORCID: https://orcid.org/0000-0002-4826-8861)
- Liuping Wei
- Sam Sansome
- Shixian Feng
- Zhongxi Fu (ORCID: https://orcid.org/0000-0002-4965-908X)
- Sarah Lewington (ORCID: https://orcid.org/0000-0002-4496-4771)
- Garry Lancaster
- Shuzhen Qu
- Gang Zhou (ORCID: https://orcid.org/0000-0001-6887-4108)
- Xiaocao Tian (ORCID: https://orcid.org/0000-0002-4275-3719)
- Xunfu Zhong
- Rory Collins (ORCID: https://orcid.org/0000-0001-8288-8602)
- Yun Liu (ORCID: https://orcid.org/0000-0002-4311-3772)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-4819-6482)
- Yanjun Wang (ORCID: https://orcid.org/0000-0002-6450-5302)
- Libo Zhang (ORCID: https://orcid.org/0000-0001-7072-4408)
- Jianguo Li (ORCID: https://orcid.org/0000-0002-6271-5584)
- Hongmei Wang (ORCID: https://orcid.org/0000-0002-7515-6363)
- Yiping Chen (ORCID: https://orcid.org/0000-0002-4973-0296)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-2049-3485)
- Lin Wang (ORCID: https://orcid.org/0000-0002-3889-5714)
- Hua Zhang (ORCID: https://orcid.org/0000-0001-7704-4712)
- Liming Li (ORCID: https://orcid.org/0000-0002-5798-2362)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-5521-2092)
- Hao Wang (ORCID: https://orcid.org/0000-0002-9131-0199)
- Shuo Zhang (ORCID: https://orcid.org/0000-0001-9497-6263)
- Yin Li (ORCID: https://orcid.org/0000-0003-2008-9738)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1225-0173)
- Xiaoping Wang (ORCID: https://orcid.org/0000-0002-4909-8286)
- Bo Yu (ORCID: https://orcid.org/0000-0002-1635-0027)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Weiyuan Zhang (ORCID: https://orcid.org/0000-0002-9758-4123)
- Yihe Hu (ORCID: https://orcid.org/0000-0002-1340-1474)
- Lei Fan (ORCID: https://orcid.org/0000-0002-4733-672X)
- Xiaofang Chen (ORCID: https://orcid.org/0000-0003-2058-5731)
- Yanjie Li (ORCID: https://orcid.org/0000-0002-9545-6179)
- Wei Hou (ORCID: https://orcid.org/0000-0003-1441-0708)
- Xin Xu (ORCID: https://orcid.org/0000-0003-0748-3669)
- Junzheng Wang (ORCID: https://orcid.org/0000-0002-7351-2643)
- Ding Zhang (ORCID: https://orcid.org/0000-0002-0044-5451)
- Yongmei Liu (ORCID: https://orcid.org/0000-0001-6033-8343)
- Shaojie Wang (ORCID: https://orcid.org/0000-0003-2706-3581)
- Chunmei Wang (ORCID: https://orcid.org/0000-0001-8104-6892)
- Pengfei Ge (ORCID: https://orcid.org/0000-0002-9270-4106)
- Junshi Chen (ORCID: https://orcid.org/0000-0001-5530-1343)
- Ran Tao (ORCID: https://orcid.org/0000-0003-0237-4623)
- Xuefeng Tang (ORCID: https://orcid.org/0000-0002-1895-4617)
- Liyuan Zhou (ORCID: https://orcid.org/0000-0002-8636-9217)
- Donghui Jin (ORCID: https://orcid.org/0000-0001-5109-6856)
- Cheng Liang (ORCID: https://orcid.org/0000-0003-3832-0969)
- Ge Chen (ORCID: https://orcid.org/0000-0003-0828-9593)
- Lingli Chen
- Xiangyang Zheng (ORCID: https://orcid.org/0000-0003-3346-3979)
- Xiaolan Ren
- Biyun Chen (ORCID: https://orcid.org/0000-0002-4672-5643)
- Huimei Li (ORCID: https://orcid.org/0000-0003-2608-0283)
- Liqiu Yang
- Zhenwang Fu
- Kuang Lin
- Jinhuai Meng
- Ling Kong
- Yu‐Mei Chang (ORCID: https://orcid.org/0000-0001-6388-9626)
- Alex Hacker
- Jingchao Liu
- Ruqin Gao
- Hui He
- Zhe Qiu
- Qiang Sun (ORCID: https://orcid.org/0000-0002-3359-9465)
- Paul Ryder
- Ningmei Zhang
- Yidan Zhang (ORCID: https://orcid.org/0000-0001-7199-4709)
- Min Weng
- Qiaohua Xu (ORCID: https://orcid.org/0000-0002-7974-6125)
- Yilei Li
- Ximin Hu
- Yu Guo (ORCID: https://orcid.org/0000-0002-8303-8041)
- Ge Jiang
- Yu Ma (ORCID: https://orcid.org/0009-0006-2141-6146)
- Dongxia Pan
- Simon Gilbert
- Guojin Luo
- Qinai Xu
- Huilin Liu (ORCID: https://orcid.org/0000-0001-5193-053X)
- Youping Xiong
- Xiaoming Yang
- Xue Zhou (ORCID: https://orcid.org/0009-0008-7237-8260)
- Huarong Sun
- Yijian Qian
- Zheng Bian
- Zhenzhu Tang (ORCID: https://orcid.org/0000-0002-2352-2616)
- Huajun Long (ORCID: https://orcid.org/0000-0002-7489-3943)
- Rong Pan
- Jinyi Zhou
- John McDonnell
- Jiaojiao Ren
- Liangcai Ma
- Pei Pei (ORCID: https://orcid.org/0000-0002-5741-6563)
Institutions
- Harvard University (US)
- Peking University (CN)
- Ministry of Education (RO)
- Cancer Research And Biostatistics (US)
- Nuffield Health (GB)
- Liu Zhou Center for Disease Prevention and Control (CN)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- China National Center for Food Safety Risk Assessment (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1161/circresaha.124.325066
- Citations
- 17
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Medical Research Council