Selective Voltammetric Determination of Paracetamol and Acyclovir on an Electrode Modified with Reduced Graphene Oxide and Gold Particles

The electrooxidation of acyclovir (ACv) and paracetamol (PC) on a glassy carbon electrode (GCE) coated with reduced graphene oxide (GO red ) and electrodeposited gold particles (Au/GO red /GCE) was studied. The separation of the oxidation peaks of PC and ACv on the Au/GO red /GCE was achieved by decreasing overvoltage. А selective and highly sensitive voltammetric method for the simultaneous determination of PC and ACv was developed. The linear dynamic range of PC and ACv was from 5×10 -3 to 5×10 -8 M. The proposed method was successfully applied to detect non-metabolized forms of PC and ACv in the presence of human urine.