Two new phenolic glycosides from the roots of <i>Iris domestica</i> (L.) Goldblatt & Mabb and their cytotoxic activity
Two new phenolic glycosides, Diplostephioside D (<b>1</b>) and Diplostephioside E (<b>2</b>) together with ten known phenols (<b>3</b>-<b>12</b>) were isolated from the dried roots of <i>Iris domestica</i> (L.) Goldblatt & Mabb. Among them, compounds <b>4</b>-<b>9</b> have not been reported previously from the family Iridaceae. The chemical structures were elucidated based on extensive spectroscopic experiments, including 1D and 2D NMR as well as HR-ESI-MS, and comparison with those reported in the literature. All of the isolated compounds were evaluated for their cytotoxic activity against HeLa cells. Compounds <b>1</b>, <b>2</b>, <b>4</b>, <b>8</b> and <b>12</b> showed cytotoxic activities with IC<sub>50</sub> values ranging from 13.52 ± 1.52 to 53.33 ± 1.40 μM.
Authors
- Tieqiang Zong (ORCID: https://orcid.org/0000-0002-6190-0286)
- Jinfeng Sun (ORCID: https://orcid.org/0000-0002-5576-1654)
- Mei Jin (ORCID: https://orcid.org/0000-0002-6992-9243)
- Lantian Cui
- Zhengyu Hu (ORCID: https://orcid.org/0000-0003-1721-7321)
- Wei Zhou (ORCID: https://orcid.org/0000-0003-3901-6061)
- Gao Li (ORCID: https://orcid.org/0000-0002-1722-8859)
- Pengcheng Yang (ORCID: https://orcid.org/0000-0003-0374-4446)
- Mingxia Li (ORCID: https://orcid.org/0000-0002-6941-7344)
Institutions
- Yanbian University (CN)
- Yanbian University Hospital (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1080/14786419.2024.2404659
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China