Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights
<b>Aim:</b> To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.<b>Materials & methods:</b> Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using <i>in vitro</i> assays and molecular docking studies.<b>Results:</b> The complexes exhibited significant antimalarial activity against <i>Plasmodium falciparum</i>, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.
Authors
- Aisha Tufail (ORCID: https://orcid.org/0000-0001-7349-9162)
- Amit Dubey (ORCID: https://orcid.org/0000-0003-0737-0488)
- Nasir Tufail (ORCID: https://orcid.org/0009-0005-2137-3804)
- Anisha Bhardwaj (ORCID: https://orcid.org/0009-0009-2682-2831)
- Sapana Garg (ORCID: https://orcid.org/0000-0002-9336-203X)
- Manish Kumar (ORCID: https://orcid.org/0000-0001-7867-3967)
Institutions
- University of Allahabad (IN)
- Saveetha University (IN)
- Maharshi Dayanand University (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1080/17568919.2024.2401310
- Citations
- 5
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 1.41