Development of novel ionization chambers for reference dosimetry in electron flash radiotherapy
This study confirmed that the CCE of ion chambers depends strongly on the electrode spacing and the electric field strength, and also on the DPP and the PW of the UHDR beam. A significant finding of this study is that although chamber performance does depend on PW, the effect on the CCE becomes negligible with reduced electrode spacing and increased electric field. A CCE of ≥95% was achieved for DPPs of up to 5 Gy with no observable dependence on PW using the A30 chamber, while still achieving an acceptable performance in conventional dose rate beams, opening up the possibility for this type of chamber to be used as a reference class chamber for calibration purposes of electron FLASH beamlines.
Authors
- Ahtesham Ullah Khan (ORCID: https://orcid.org/0000-0002-0340-572X)
- Sam Beddar (ORCID: https://orcid.org/0000-0001-5825-110X)
- Shannon Holmes
- Larry A. DeWerd (ORCID: https://orcid.org/0000-0003-2003-2344)
- Brian D. Hooten
- Kevin Liu (ORCID: https://orcid.org/0000-0002-0942-6513)
- Emil Schüler
Institutions
- Northwestern University (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Wisconsin–Madison (US)
- Northwestern Memorial Hospital (US)
- Standard Imaging (United States) (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Medical Physics
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1002/mp.17425
- Citations
- 15
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 6.28
Funders
- Cancer Prevention and Research Institute of Texas
- University of Texas Health Science Center at Houston
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Cancer Institute