Multiancestry transferability of a polygenic risk score for diverticulitis
Associations between a diverticular disease PRS and severe presentations persisted in diverse cohorts when controlling for known risk factors. Relative improvements in model performance were observed, but absolute change magnitudes were modest.
Authors
- John P. Shelley (ORCID: https://orcid.org/0000-0002-8612-3022)
- Jamie R. Robinson (ORCID: https://orcid.org/0000-0003-0888-0156)
- Christopher J. Neylan (ORCID: https://orcid.org/0000-0002-6458-4485)
- Richard M. Peek (ORCID: https://orcid.org/0000-0002-4836-5960)
- Lillias H. Maguire (ORCID: https://orcid.org/0000-0002-6041-2416)
- Alexander T. Hawkins (ORCID: https://orcid.org/0000-0002-8531-7247)
- Thomas E. Ueland (ORCID: https://orcid.org/0000-0001-6618-9318)
- Eric R. Gamazon (ORCID: https://orcid.org/0000-0003-4204-8734)
- Jonathan D. Mosley (ORCID: https://orcid.org/0000-0001-6421-2887)
Institutions
- Saint Thomas Health (US)
- Vanderbilt University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- BMJ Open Gastroenterology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1136/bmjgast-2024-001474
- Primary Topic
- Diverticular Disease and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences