Increased Frequency of Circulating Activated FOXP3+ Regulatory T Cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the Estimate of the Size of the Tumor Mass, STAT5 Signaling and Disease Course during Follow-Up of Patients
The results suggesting that an aTreg fraction could represent a possible marker of a severe disease course with infectious complications. Augmented homeostatic STAT5 signalling could support aTreg expansion, as higher pSTAT5 levels were significantly correlated with an increased aTreg frequency among CD4<sup>+</sup>FOXP3<sup>+</sup> T cells during the follow-up of patients on therapy, as well as following SARS-CoV-2 antigen-specific stimulation in vitro.
Authors
- Aleš Goropevšek (ORCID: https://orcid.org/0000-0002-2188-578X)
- Tadej Avčin (ORCID: https://orcid.org/0000-0001-8409-9092)
- Sebastjan Bevc (ORCID: https://orcid.org/0000-0003-2313-1559)
- Evgenija Homšak (ORCID: https://orcid.org/0000-0003-3904-1814)
- Zlatko Roškar
- Mojca Dreisinger
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- University of Maribor (SI)
- University Clinical Centre Maribor (SI)
Publication Details
- Journal
- Cancers
- Published
- 2024-09-22
- DOI
- https://doi.org/10.3390/cancers16183228
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00