Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx
Glycocalyx shedding and MMPs play key roles in IAV-induced epithelial injury, with significant impact on IAV viral load. Further studies are needed to understand which specific MMPs regulate lung epithelial glycocalyx shedding.
Authors
- Stuart R. Landstreet (ORCID: https://orcid.org/0009-0003-9599-1248)
- Ciara M. Shaver (ORCID: https://orcid.org/0000-0002-5677-0288)
- Lorraine B. Ware (ORCID: https://orcid.org/0000-0002-9429-4702)
- Dustin Gibson
- Julie A. Bastarache (ORCID: https://orcid.org/0000-0003-0458-6507)
- Kaitlyn Schaaf (ORCID: https://orcid.org/0000-0002-8473-6642)
- Jennifer M. S. Sucre (ORCID: https://orcid.org/0000-0002-6613-1439)
- Samantha K. Gonski
- Charity J. Buggs
- Eric P. Schmidt (ORCID: https://orcid.org/0000-0002-7360-0504)
- Christophe Langouët-Astrié (ORCID: https://orcid.org/0000-0002-1867-3815)
- Jason Lin (ORCID: https://orcid.org/0009-0002-3574-5953)
- Christopher S. Jetter (ORCID: https://orcid.org/0000-0002-3826-5843)
- Nathan D. Putz
- Nicolas M Negretti
Institutions
- Vanderbilt University (US)
- Massachusetts General Hospital (US)
- Monroe Carell Jr. Children's Hospital (US)
- University of Colorado Anschutz Medical Campus (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1371/journal.pone.0308648
- Citations
- 6
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 2.51
Funders
- Vanderbilt University