SIRT7 protects against liver fibrosis by suppressing stellate cell activation via TGF-β/SMAD2/3 pathway
Our findings revealed previously unidentified role of SIRT7 in regulating HSCs activation via modulating TGF-β/SMAD2/3 signaling pathway. Targeting SIRT7 might offer novel therapeutic option against liver fibrosis.
Authors
- Zhuan Li (ORCID: https://orcid.org/0000-0002-1310-4584)
- Cong Ding (ORCID: https://orcid.org/0000-0002-6808-9975)
- Yiying Gu (ORCID: https://orcid.org/0000-0002-6126-4590)
- Tingzi Yu
- Bohao Liu (ORCID: https://orcid.org/0000-0001-8271-7379)
- Jinying Peng (ORCID: https://orcid.org/0000-0003-2679-856X)
- Zhiqiang Wang
Institutions
- Hunan Normal University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1016/j.biopha.2024.117477
- Citations
- 6
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.22