Mpox Recurrence and Tecovirimat Resistance in a Patient With Advanced Human Immunodeficiency Virus Disease
We present a case of mpox recurrence in a transgender woman with AIDS. Her recurrent lesions required several courses of antiviral therapy over a 5-month period and her monkeypox viral genome was subsequently noted to have tecovirimat resistance mutations. Interestingly, she developed a robust orthopoxvirus-specific T-cell response.
Authors
- Heba H. Mostafa (ORCID: https://orcid.org/0000-0002-0274-8966)
- Joel N. Blankson (ORCID: https://orcid.org/0000-0002-9683-8021)
- Mihaela Carter
- Bhakti Hansoti (ORCID: https://orcid.org/0000-0003-0188-9764)
- Kelly A. Gebo (ORCID: https://orcid.org/0000-0003-4010-398X)
- Amary Fall (ORCID: https://orcid.org/0000-0002-6890-7915)
- Caroline C. Traut
- Joel Sop
- David C Griffith (ORCID: https://orcid.org/0000-0002-3818-4226)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1093/ofid/ofae549
- Citations
- 5
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Harvard University Center for AIDS Research
- Johns Hopkins University Press