Antiviral potential of phenolic compounds against HSV-1: In-vitro study
Our findings suggest that quercetin at concentrations of 62 and 125 µM significantly reduced HSV-1 infectivity, as well as these two concentrations of quercetin showed a significant difference in virus reduction compared with acyclovir (10 µM) at certain time points. The anti-inflammatory properties of quercetin, in contrast to acyclovir, make it a potential candidate for anti HSV-1 treatment in life-threatening conditions such as Herpes encephalitis. Additionally, doxorubicin, an anticancer drug, showed meaningful inhibition of HSV-1 at non-toxic concentrations of 2 and 8 µM, suggesting its potential interference with HSV-1 in viral-oncolytic therapy in cancer treatment.
Authors
- Ali Teimoori (ORCID: https://orcid.org/0000-0003-0766-8591)
- Shahab Mahmoudvand (ORCID: https://orcid.org/0000-0002-9155-9939)
- Reza Ghanbari (ORCID: https://orcid.org/0000-0001-9296-4293)
- Farid Azizi Jalilian (ORCID: https://orcid.org/0000-0003-3134-1441)
- Shahrzad Zangooie (ORCID: https://orcid.org/0009-0002-4091-9583)
Institutions
- Hamedan University of Medical Sciences (IR)
- Shariati Hospital (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Antiviral Therapy
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1177/13596535241271589
- Citations
- 5
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Hamadan University of Medical Sciences