Remimazolam attenuates lipopolysaccharide-induced neuroinflammation and cognitive dysfunction
Remimazolam demonstrated neuroprotective and anti-neuroinflammatory effects in a mouse model of LPS-induced cognitive impairment. These effects are likely mediated through the regulation of TSPO, which inhibits microglial activation and promotes the polarization of microglia from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype.
Authors
- Yan Wang (ORCID: https://orcid.org/0000-0003-4940-0542)
- Shenghua Chen (ORCID: https://orcid.org/0000-0002-0898-5292)
- Leguang Zhou
- Chengxi Liu (ORCID: https://orcid.org/0000-0002-5182-542X)
- Wenjie Liu (ORCID: https://orcid.org/0000-0002-8044-5338)
- Lijuan Wang (ORCID: https://orcid.org/0000-0001-8910-2617)
- Shangtao Zhou
- Mengzhe Xiao
- Hongzhao Shi
Institutions
- University of South China (CN)
Publication Details
- Journal
- Behavioural Brain Research
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1016/j.bbr.2024.115268
- Citations
- 20
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.95