Carnitine is a friend in HFpEF and foe in HFrEF
Heart failure (HF) is a global concern, particularly HF with preserved ejection fraction (HFpEF), lacking effective treatments. Understanding the differences of metabolic profiles between HFpEF and HFrEF (heart failure with reduced ejection fraction) patients is crucial for therapeutic advancements. In this study, pseudotargeted metabolomics was employed to analyze for disparities of plasma metabolic profiles between HFpEF and HFrEF in two cohorts: discovery (<i>n</i> = 514) and validation (<i>n</i> = 3368). Plasma-free carnitine levels were significant changed in HF patients. A non-linear and U-shaped (for HFpEF) or J-shaped (for HFrEF) association between circulating free carnitine levels and the composite risk of cardiac events were observed. Interestingly, HFpEF patients with low free carnitine (≤40.18 μmol/L) displayed a poorer survival, contrasting with HFrEF where higher levels (≥35.67 μmol/L) were linked to poorer outcomes, indicating distinct metabolism pathways. In conclusion, these findings offer insights into HFpEF metabolic profiles, suggesting potential therapeutic targets.
Authors
- Yansong Guo (ORCID: https://orcid.org/0000-0001-6607-6938)
- Dao Wen Wang (ORCID: https://orcid.org/0000-0002-9774-3980)
- Ji Liang (ORCID: https://orcid.org/0000-0002-0429-9236)
- Bing Pan (ORCID: https://orcid.org/0000-0001-8907-8100)
- Haoran Wei (ORCID: https://orcid.org/0000-0001-6566-6602)
- Yu‐Fei Wu (ORCID: https://orcid.org/0000-0002-3970-3999)
- Hongtu Cui (ORCID: https://orcid.org/0009-0000-7577-5677)
- Min Fei
- Xin Li (ORCID: https://orcid.org/0000-0002-4018-6220)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-5803-2556)
- Qingyuan Liu (ORCID: https://orcid.org/0009-0008-6284-2963)
- Junfang Wu (ORCID: https://orcid.org/0000-0001-9842-0414)
- Lu Fang (ORCID: https://orcid.org/0000-0003-3552-0367)
- Lemin Zheng (ORCID: https://orcid.org/0000-0003-4473-6936)
- Huiqing Wang (ORCID: https://orcid.org/0000-0002-3618-1603)
- Mingming Zhao
- Nan Lin
- Xiaodong Yao
- Yujie Zhu
- Wenxin Shan
- Rui Zhan (ORCID: https://orcid.org/0000-0002-8930-8911)
Institutions
- Qingdao University (CN)
- Peking University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Peking University Third Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-09-23
- DOI
- https://doi.org/10.1016/j.isci.2024.111018
- Citations
- 4
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation
- National High-tech Research and Development Program